DSIP 5mg

Overview

DSIP (delta sleep-inducing peptide) is a nine-residue neuropeptide isolated in 1977 from the cerebral venous blood of rabbits during electrically induced sleep. Its name comes from the delta-wave EEG activity reported in the original experiments. Nearly fifty years later its receptor and precise physiological role remain unresolved, which is why it continues to be a subject of neuropeptide research.

Acu Aminos supplies DSIP as a 5 mg lyophilized powder for laboratory research.

Chemistry & specifications

DSIP is a small, acidic, unmodified nonapeptide with a free N-terminal tryptophan and free C-terminal carboxylate. Its high glycine content gives it a flexible, largely unstructured conformation in solution. It is rapidly degraded by peptidases, and phosphorylated and D-amino-acid analogs have been synthesized in the literature to study stability.

Cellular structure & mechanism of action

No dedicated DSIP receptor has been identified. Published work proposes interactions with GABAergic and glutamatergic transmission, modulation of the hypothalamic-pituitary-adrenal axis (reduced ACTH and corticotropin-releasing-hormone release in some models), and effects on MAO-A activity and oxidative stress in neuronal tissue. Its EEG effects in animal models have been inconsistent across laboratories, and the compound is often cited as an example of a bioactive peptide whose mechanism is still open. DSIP-like immunoreactivity has been detected in the hypothalamus, pituitary and gut, suggesting a peptide precursor that has not been fully characterized.

Research applications

• Neuropeptide receptor-identification and binding studies
• EEG and sleep-architecture research in animal models
• HPA-axis and stress-hormone signaling assays
• Peptide stability and analog structure-activity research

Selected references

1. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci USA. 1977;74(3):1282–1286.
2. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303–309.
3. Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): an update. Peptides. 1986;7(6):1165–1187.

References are provided to help researchers locate primary literature. Acu Aminos makes no claims about the safety or efficacy of any compound in humans or animals.