Growth Hormone Secretagogues

Ipamorelin 10mg

Name: Ipamorelin 10mg
Brand: Acu Aminos
SKU: ACU-IPA-10
Price: 54.99 USD
Availability: InStock

$54.99

Synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂), 10 mg lyophilized. A selective agonist of the growth hormone secretagogue receptor (GHS-R1a) used in receptor-pharmacology and endocrine-signaling research. ≥99% purity. Research use only.

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Research Grade

99% Purity

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SKUACU-IPA-10
FormLyophilized powder
Purity≥99% (HPLC)
StorageLyophilized at -20C (2-8C short term)

Overview

Ipamorelin is a synthetic pentapeptide developed by Novo Nordisk in the 1990s as a growth hormone secretagogue. It was the first compound in its class reported to release growth hormone in animal models with high selectivity, without the concomitant ACTH and cortisol release seen with earlier GHRP compounds. It acts as an agonist at the ghrelin receptor (GHS-R1a).

Acu Aminos supplies Ipamorelin as a 10 mg lyophilized powder for receptor-binding, signaling and endocrine-cell research.

Research use only. This product is supplied as a lyophilized reference material for laboratory and in-vitro research. It is not a drug, is not for human or veterinary use, and no dosing, reconstitution or administration information is provided. The summary below describes published chemistry and mechanism-of-action literature for research reference only.

Chemistry & specifications

Ipamorelin contains two non-natural residues, α-aminoisobutyric acid (Aib) at the N-terminus and D-2-naphthylalanine, plus a D-phenylalanine, all of which confer resistance to proteolysis. The C-terminus is amidated. The aromatic D-2-Nal and D-Phe side chains are considered essential for receptor binding, mirroring the pharmacophore of the earlier GHRP series.

Sequence	Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Molecular formula	C₃₈H₄₉N₉O₅
Molecular weight	711.9 g/mol
CAS	170851-70-4
Net content	10 mg per vial
Form	Lyophilized powder
Purity	≥99% (HPLC)
Appearance	White lyophilized powder
Solubility	Water soluble
Storage	Lyophilized: −20 °C long term, 2–8 °C short term. Protect from light and moisture.

Cellular structure & mechanism of action

GHS-R1a is a G-protein-coupled receptor expressed in the pituitary and hypothalamus, as well as in peripheral tissues. Agonist binding activates Gα_q/11, stimulating phospholipase C, inositol-trisphosphate production and an increase in intracellular calcium in somatotroph cells. In the original characterization, Ipamorelin displayed a potency comparable to GHRP-6 in rat pituitary cell assays while showing markedly less effect on ACTH, cortisol and prolactin, which is why it is often used as a selective reference agonist in GHS-R pharmacology.

Research applications

GHS-R1a receptor binding and functional (calcium-flux) assays
Somatotroph cell signaling and secretion models in vitro
Ghrelin-receptor structure-activity relationship studies
Comparative secretagogue selectivity research

Selected references

Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552–561.
Johansen PB, Nowak J, Skjaerbaek C, et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res. 1999;9(2):106–113.
Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656–660.

References are provided to help researchers locate primary literature. Acu Aminos makes no claims about the safety or efficacy of any compound in humans or animals.

Peptide Primer

What are research peptides?

Structure

Peptides are chains of amino acids joined by amide (peptide) bonds. Short chains of 2 to roughly 50 residues are called peptides; longer chains fold into proteins. Sequence, chain length and terminal modifications define how a peptide behaves.

Synthesis & purity

Research peptides are built by solid-phase peptide synthesis, cleaved from the resin, purified by reverse-phase HPLC and lyophilized to a stable powder. Purity is reported as the HPLC area percentage of the target peak; identity is confirmed by mass spectrometry.

Laboratory use

In the lab, peptides serve as receptor ligands, enzyme substrates, signaling probes and reference standards in cell-culture, biochemical and analytical studies. Our products are supplied exclusively for these in-vitro research applications.

Handling & storage

Lyophilized peptides should be kept sealed, protected from light and moisture, and stored refrigerated or frozen for long-term stability. Allow vials to reach room temperature before opening to prevent condensation.

All information on this page is provided for educational and research reference only and does not constitute medical advice or a recommendation for use in humans or animals.