BPC-157

Overview

BPC-157 is a synthetic pentadecapeptide corresponding to a partial sequence of a protein isolated from human gastric juice. It is unusually stable in acidic environments and has been studied in a large body of preclinical literature, primarily from the University of Zagreb, in tendon, ligament, muscle, gastrointestinal and vascular tissue models.

Acu Aminos supplies BPC-157 as a lyophilized powder in 5 mg and 10 mg vials from the same lot-tested material; choose the size above.

Chemistry & specifications

BPC-157 is a linear, unmodified 15-residue peptide rich in proline (four residues) and acidic residues (Glu, two Asp). The proline-proline-proline motif restricts conformational flexibility and contributes to its reported resistance to gastric acid and peptidases. It has no cysteine, so it is not prone to oxidation or disulfide scrambling. Both the acetate and the free-base form are described in the literature; the counter-ion for each lot is stated on the COA.

Cellular structure & mechanism of action

No single receptor for BPC-157 has been confirmed. Published mechanisms from cell and animal models include modulation of the nitric-oxide system, up-regulation of growth-factor receptors such as VEGFR2 and activation of the FAK-paxillin pathway in fibroblasts, increased expression of early growth response genes (EGR-1) and their repressor NAB2, and effects on the dopamine and serotonin systems in neural tissue. In tendon-fibroblast culture it has been reported to increase cell survival under oxidative stress and to promote migration and outgrowth from tendon explants.

Research applications

• Tendon fibroblast and tenocyte migration and survival assays
• Nitric-oxide pathway and endothelial signaling studies
• Gastrointestinal mucosal-cell and barrier models
• Angiogenesis and VEGFR2 expression research

Selected references

1. Sikiric P, Seiwerth S, Rucman R, et al. Brain-gut axis and pentadecapeptide BPC 157: theoretical and practical implications. Curr Neuropharmacol. 2016;14(8):857–865.
2. Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011;110(3):774–780.
3. Seiwerth S, Rucman R, Turkovic B, et al. BPC 157 and standard angiogenic growth factors. Curr Pharm Des. 2018;24(18):1972–1989.

References are provided to help researchers locate primary literature. Acu Aminos makes no claims about the safety or efficacy of any compound in humans or animals.