GLOW 70mg

Overview

GLOW is a co-lyophilized blend of three of the most studied tissue-signaling peptides: the copper tripeptide GHK-Cu, the gastric pentadecapeptide BPC-157, and Thymosin β4 (TB-500). Each is a well-characterized research compound in its own right; the blend exists so that laboratories comparing single-agent and combined signaling in extracellular-matrix, fibroblast and cell-migration models can work from a single reference vial with one lot COA.

Acu Aminos supplies GLOW as a 70 mg lyophilized powder (50 / 10 / 10 mg). Individual vials of GHK-Cu, BPC-157 and TB-500 are also available.

Chemistry & specifications

GHK-Cu (Gly-His-Lys · Cu²⁺, ≈403.9 g/mol) is a copper chelate that delivers copper to cuproenzymes and interacts with proteoglycans. BPC-157 (GEPPPGKPADDAGLV, 1419.5 g/mol) is a stable, proline-rich 15-residue fragment of a gastric protein. Thymosin β4 (43 residues, ≈4963 g/mol) is the principal G-actin-sequestering peptide in mammalian cells. All three are water soluble and are co-lyophilized without excipients; the lot COA reports HPLC purity for each component.

Cellular structure & mechanism of action

The three components act through distinct mechanisms that are frequently studied together. GHK-Cu has been reported to modulate collagen, glycosaminoglycan and metalloproteinase gene expression and to act as a chemoattractant for fibroblasts and immune cells in vitro. BPC-157 has been reported to influence the nitric-oxide system, VEGFR2 signaling and fibroblast migration in cell and animal models. Thymosin β4 sequesters monomeric actin, promotes endothelial and keratinocyte migration, and activates ILK/Akt signaling in cardiac and epithelial cells. Combined studies examine whether matrix-remodeling, angiogenic and cytoskeletal signals are additive in wound-model and tissue-culture systems.

Research applications

• Fibroblast and keratinocyte migration (scratch) assays, single agent vs. blend
• Extracellular-matrix synthesis and MMP/TIMP balance studies
• Angiogenesis and endothelial tube-formation models
• Multi-peptide signaling and combination-effect research

Selected references

1. Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. Int J Mol Sci. 2018;19(7):1987.
2. Seiwerth S, Rucman R, Turkovic B, et al. BPC 157 and standard angiogenic growth factors. Gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Curr Pharm Des. 2018;24(18):1972–1989.
3. Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005;11(9):421–429.

References are provided to help researchers locate primary literature. Acu Aminos makes no claims about the safety or efficacy of any compound in humans or animals.