Metabolic & Incretin Peptides

Tirzepatide 30mg

Name: Tirzepatide 30mg
Brand: Acu Aminos
SKU: ACU-TRZ-30
Price: 139.99 USD
Availability: InStock

$139.99

LY3298176, a 39-residue lipidated peptide with dual agonist activity at GIP and GLP-1 receptors, 30 mg lyophilized. For incretin-receptor pharmacology, biased-signaling and metabolic cell-model research. ≥99% purity. Research use only.

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Research Grade

99% Purity

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SKUACU-TRZ-30
FormLyophilized powder
Purity≥99% (HPLC)
StorageLyophilized at -20C (2-8C short term)

Overview

Tirzepatide (LY3298176) is a synthetic single-chain peptide built on the GIP sequence and engineered to activate both the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R). It is the archetypal “twincretin” and the most widely referenced dual incretin agonist in current receptor-pharmacology literature.

Acu Aminos supplies Tirzepatide as a 30 mg lyophilized powder for laboratory research.

Research use only. This product is supplied as a lyophilized reference material for laboratory and in-vitro research. It is not a drug, is not for human or veterinary use, and no dosing, reconstitution or administration information is provided. The summary below describes published chemistry and mechanism-of-action literature for research reference only.

Chemistry & specifications

Tirzepatide is a 39-amino-acid peptide with α-aminoisobutyric acid (Aib) substitutions at positions 2 and 13 to resist DPP-4 cleavage, and a C20 fatty-diacid attached to the lysine at position 20 through a γ-glutamate and two 8-amino-3,6-dioxaoctanoic acid (OEG) spacers. The lipid moiety binds albumin, extending half-life in biological systems. The C-terminus is amidated.

Designation	LY3298176
Length	39 amino acids, lipidated (C20 diacid via γGlu-2×OEG at Lys20)
Molecular formula	C₂₂₅H₃₄₈N₄₈O₆₈
Molecular weight	4813.5 g/mol
CAS	2023788-19-2
Net content	30 mg per vial
Form	Lyophilized powder
Purity	≥99% (HPLC)
Appearance	White lyophilized powder
Storage	Lyophilized: −20 °C long term, 2–8 °C short term. Protect from light and moisture.

Cellular structure & mechanism of action

GIPR and GLP-1R are class B GPCRs that signal through Gα_s-mediated cAMP production. Pharmacological characterization shows Tirzepatide binds GIPR with affinity comparable to native GIP while binding GLP-1R with lower affinity than native GLP-1, and it displays biased signaling at GLP-1R, favoring cAMP generation over β-arrestin recruitment and receptor internalization. These properties make it a widely used tool compound for studying imbalanced and biased agonism at incretin receptors and for comparing dual-agonist signaling with selective GLP-1R agonists in islet, adipocyte and neuronal cell models.

Research applications

GIPR and GLP-1R binding, cAMP and β-arrestin recruitment assays
Biased-agonism and receptor-internalization studies
β-cell, adipocyte and hypothalamic-neuron signaling models
Lipidated-peptide albumin binding, stability and analytical method development

Selected references

Coskun T, Sloop KW, Loghin C, et al. LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept. Mol Metab. 2018;18:3–14.
Willard FS, Douros JD, Gabe MB, et al. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. JCI Insight. 2020;5(17):e140532.
Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide once weekly for the treatment of obesity. N Engl J Med. 2022;387(3):205–216.

References are provided to help researchers locate primary literature. Acu Aminos makes no claims about the safety or efficacy of any compound in humans or animals.

Peptide Primer

What are research peptides?

Structure

Peptides are chains of amino acids joined by amide (peptide) bonds. Short chains of 2 to roughly 50 residues are called peptides; longer chains fold into proteins. Sequence, chain length and terminal modifications define how a peptide behaves.

Synthesis & purity

Research peptides are built by solid-phase peptide synthesis, cleaved from the resin, purified by reverse-phase HPLC and lyophilized to a stable powder. Purity is reported as the HPLC area percentage of the target peak; identity is confirmed by mass spectrometry.

Laboratory use

In the lab, peptides serve as receptor ligands, enzyme substrates, signaling probes and reference standards in cell-culture, biochemical and analytical studies. Our products are supplied exclusively for these in-vitro research applications.

Handling & storage

Lyophilized peptides should be kept sealed, protected from light and moisture, and stored refrigerated or frozen for long-term stability. Allow vials to reach room temperature before opening to prevent condensation.

All information on this page is provided for educational and research reference only and does not constitute medical advice or a recommendation for use in humans or animals.