Metabolic & Incretin Peptides

Retatrutide

Name: Retatrutide
Brand: Acu Aminos
SKU: ACU-RET
Price: 109.99 USD
Availability: InStock

From $109.99

LY3437943, an engineered 39-residue lipidated peptide with agonist activity at GIP, GLP-1 and glucagon receptors, lyophilized. Available in 15 mg and 40 mg vials for incretin-receptor pharmacology and metabolic-signaling research. ≥99% purity. Research use only.

In stock. Ships within 1 business day.

Size

Clear

For research use only. Not for human consumption.

Research Grade

99% Purity

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SKUACU-RET
FormLyophilized powder
Purity≥99% (HPLC)
StorageLyophilized at -20C (2-8C short term)

Overview

Retatrutide (LY3437943) is a synthetic single-chain peptide engineered from the glucose-dependent insulinotropic polypeptide (GIP) scaffold to activate three receptors: the GIP receptor, the GLP-1 receptor and the glucagon receptor. It is one of the most-cited compounds in current incretin-biology literature and is frequently used as a reference triple agonist in receptor-pharmacology research.

Acu Aminos supplies Retatrutide as a lyophilized powder in 15 mg and 40 mg vials from the same lot-tested material; choose the size above. The 40 mg vial suits laboratories running extended experiment series that want to minimize lot-to-lot variability.

Research use only. This product is supplied as a lyophilized reference material for laboratory and in-vitro research. It is not a drug, is not for human or veterinary use, and no dosing, reconstitution or administration information is provided. The summary below describes published chemistry and mechanism-of-action literature for research reference only.

Chemistry & specifications

Retatrutide is a 39-amino-acid peptide containing two α-aminoisobutyric acid (Aib) substitutions for protease resistance and a C20 fatty-diacid moiety attached through a linker to a lysine side chain. The lipid promotes albumin binding, which extends the peptide’s half-life in biological systems. Sequence elements from GIP, GLP-1 and glucagon were balanced during discovery to tune relative potency at each receptor.

Designation	LY3437943
Length	39 amino acids, lipidated (C20 diacid)
Molecular formula	C₂₂₁H₃₄₂N₄₆O₆₈
Molecular weight	≈4731 g/mol
CAS	2381089-83-2
Net content	15 mg or 40 mg per vial
Form	Lyophilized powder
Purity	≥99% (HPLC)
Appearance	White lyophilized powder
Storage	Lyophilized: −20 °C long term, 2–8 °C short term. Protect from light and moisture.

Cellular structure & mechanism of action

All three target receptors are class B G-protein-coupled receptors that signal primarily through Gα_s, raising intracellular cAMP and activating PKA and Epac pathways. In cell-based assays, Retatrutide displays full or near-full agonism at GIPR and GLP-1R and partial-to-full agonism at GCGR, with reported potencies characterized in the discovery publication. The combination is studied for how simultaneous engagement of the three receptors alters downstream signaling in pancreatic, hepatic and adipose cell models relative to single- or dual-agonist reference peptides.

Research applications

GIPR, GLP-1R and GCGR cAMP-accumulation and β-arrestin recruitment assays
Receptor selectivity and biased-agonism comparisons
Islet, hepatocyte and adipocyte signaling models
Lipidated-peptide albumin-binding and stability studies

Selected references

Coskun T, Urva S, Roell WC, et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept. Cell Metab. 2022;34(9):1234–1247.
Jastreboff AM, Kaplan LM, Frías JP, et al. Triple-hormone-receptor agonist retatrutide for obesity: a phase 2 trial. N Engl J Med. 2023;389(6):514–526.

References are provided to help researchers locate primary literature. Acu Aminos makes no claims about the safety or efficacy of any compound in humans or animals.

Peptide Primer

What are research peptides?

Structure

Peptides are chains of amino acids joined by amide (peptide) bonds. Short chains of 2 to roughly 50 residues are called peptides; longer chains fold into proteins. Sequence, chain length and terminal modifications define how a peptide behaves.

Synthesis & purity

Research peptides are built by solid-phase peptide synthesis, cleaved from the resin, purified by reverse-phase HPLC and lyophilized to a stable powder. Purity is reported as the HPLC area percentage of the target peak; identity is confirmed by mass spectrometry.

Laboratory use

In the lab, peptides serve as receptor ligands, enzyme substrates, signaling probes and reference standards in cell-culture, biochemical and analytical studies. Our products are supplied exclusively for these in-vitro research applications.

Handling & storage

Lyophilized peptides should be kept sealed, protected from light and moisture, and stored refrigerated or frozen for long-term stability. Allow vials to reach room temperature before opening to prevent condensation.

All information on this page is provided for educational and research reference only and does not constitute medical advice or a recommendation for use in humans or animals.