Mitochondrial & Longevity

MOTS-c 10mg

Name: MOTS-c 10mg
Brand: Acu Aminos
SKU: ACU-MOTC-10
Price: 99.99 USD
Availability: InStock

$99.99

Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c), a 16-residue peptide encoded in mitochondrial DNA, 10 mg lyophilized. Studied in AMPK, folate-methionine cycle and metabolic-signaling research. ≥99% purity. Research use only.

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Research Grade

99% Purity

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SKUACU-MOTC-10
FormLyophilized powder
Purity≥99% (HPLC)
StorageLyophilized at -20C (2-8C short term)

Overview

MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame within the mitochondrial 12S ribosomal RNA gene, first described in 2015. It belongs to the family of mitochondrial-derived peptides (with humanin and the SHLPs) and is notable for translocating to the nucleus under metabolic stress, where it has been reported to regulate nuclear gene expression.

Acu Aminos supplies synthetic MOTS-c as a 10 mg lyophilized powder for laboratory research.

Research use only. This product is supplied as a lyophilized reference material for laboratory and in-vitro research. It is not a drug, is not for human or veterinary use, and no dosing, reconstitution or administration information is provided. The summary below describes published chemistry and mechanism-of-action literature for research reference only.

Chemistry & specifications

MOTS-c is a linear, unmodified 16-residue peptide (MRWQEMGYIFYPRKLR) with a net positive charge and two methionine residues that are susceptible to oxidation. It has no disulfide bonds and is readily water soluble.

Sequence	Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular formula	C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular weight	2174.6 g/mol
CAS	1627580-64-6
Net content	10 mg per vial
Form	Lyophilized powder
Purity	≥99% (HPLC)
Appearance	White lyophilized powder
Solubility	Water soluble
Storage	Lyophilized: −20 °C long term, 2–8 °C short term. Protect from light and moisture. Contains methionine; minimize oxidation.

Cellular structure & mechanism of action

In cell and animal models, MOTS-c has been reported to inhibit the folate cycle and de novo purine synthesis, leading to accumulation of AICAR and activation of AMP-activated protein kinase (AMPK), a master regulator of cellular energy balance. Under glucose restriction or oxidative stress, MOTS-c translocates to the nucleus and associates with stress-responsive transcription factors including NRF2, altering the expression of antioxidant and metabolic genes. Its levels have been reported to change with exercise and age in the literature, making it a frequently used probe in mitochondrial-nuclear communication research.

Research applications

AMPK activation and folate/one-carbon metabolism assays
Mitochondrial-nuclear retrograde signaling studies
Skeletal-muscle and adipocyte metabolic cell models
Mitochondrial-derived peptide comparative research (humanin, SHLPs)

Selected references

Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443–454.
Kim KH, Son JM, Benayoun BA, Lee C. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metab. 2018;28(3):516–524.
Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12:470.

References are provided to help researchers locate primary literature. Acu Aminos makes no claims about the safety or efficacy of any compound in humans or animals.

Peptide Primer

What are research peptides?

Structure

Peptides are chains of amino acids joined by amide (peptide) bonds. Short chains of 2 to roughly 50 residues are called peptides; longer chains fold into proteins. Sequence, chain length and terminal modifications define how a peptide behaves.

Synthesis & purity

Research peptides are built by solid-phase peptide synthesis, cleaved from the resin, purified by reverse-phase HPLC and lyophilized to a stable powder. Purity is reported as the HPLC area percentage of the target peak; identity is confirmed by mass spectrometry.

Laboratory use

In the lab, peptides serve as receptor ligands, enzyme substrates, signaling probes and reference standards in cell-culture, biochemical and analytical studies. Our products are supplied exclusively for these in-vitro research applications.

Handling & storage

Lyophilized peptides should be kept sealed, protected from light and moisture, and stored refrigerated or frozen for long-term stability. Allow vials to reach room temperature before opening to prevent condensation.

All information on this page is provided for educational and research reference only and does not constitute medical advice or a recommendation for use in humans or animals.